TY  -  JOUR
AU  -  Salati, Massimiliano
AU  -  Caputo, Francesco
AU  -  Cerma, Krisida
AU  -  Marcheselli, Luigi
AU  -  Braconi, Chiara
AU  -  Cascinu, Stefano
T1  -  The impact of gender and immune system determinants on long-term survival in biliary tract cancer
PY  -  2019
Y1  -  2019-01-01
DO  -  10.1723/3148.31296
JO  -  The Italian Journal of Gender-Specific Medicine
JA  -  Ital J Gender-Specific Med
VL  -  5
IS  -  1
SP  -  27
EP  -  30
PB  -  Il Pensiero Scientifico Editore
SN  -  2612-3487
Y2  -  2026/04/15
UR  -  http://dx.doi.org/10.1723/3148.31296
N2  -  Summary. Advanced biliary tract cancers are poor prognosis tumors with limited therapeutic options. The conventional treatment consists of combination chemotherapy resulting in overall survival of less than 12 months. Recently, a subgroup of patients characterized by an exceedingly favorable prognosis has been reported in the literature. In our study, we assessed the prevalence and provided a clinicopathological characterization of this subset of patients in the context of daily practice. In particular, we were able to identify female sex and neutrophil-to-lymphocyte ratio as independent predictors of long-term survival. Based on these premises, we deem it necessary to prompt translational research projects aimed at molecularly characterized long-term survivors, particularly focusing on sex- and immune-related determinants.
ER  -