TY  -  JOUR
AU  -  Nouri-Pasovsky, Pauline Assina
AU  -  Nachtigall, Irit
AU  -  Krannich, Alexander
AU  -  Spies, Claudia
AU  -  Tafelski, Sascha
T1  -  Evaluation of sex-associated differences in validity of the SOFA score in ICU patients
PY  -  2021
Y1  -  2021-01-01
DO  -  10.1723/3528.35161
JO  -  The Italian Journal of Gender-Specific Medicine
JA  -  Ital J Gender-Specific Med
VL  -  7
IS  -  1
SP  -  7
EP  -  14
PB  -  Il Pensiero Scientifico Editore
SN  -  2612-3487
Y2  -  2026/04/15
UR  -  http://dx.doi.org/10.1723/3528.35161
N2  -  Summary. Background. Most of intensive care scoring systems are helpful to objectively assess the severity of an illness and morbidity. Therefore, scoring systems are used to assess the probability of mortality in ICU-patients and to compare patient populations. Recently, SOFA-score was incorporated into sepsis definition models to improve discrimination of patient populations. During the last decades, sex was recognized as a relevant factor that invoked the need for novel, sex-oriented, approaches to therapy. To date, data evaluating sex-related differences in intensive care scoring systems are not available and current scoring systems may be less precise to women. Therefore, the aim of this study was to explore the validity of different intensive care scoring systems from a sex perspective. Methods. In five surgical intensive care units (ICUs) patients were evaluated including daily assessment of 3 different scoring systems (SOFA, SAPS-II, TISS-28). First obtained scores on ICU admission were assessed for sex-specific discrimination of ICU mortality. Results . Altogether 1,862 patients fulfilled inclusion criteria. Men showed statistical significant higher admission SOFA-score-values compared to women (5.5 ± 4.1 versus 4.6 ± 3.6, p = <0.001), but mortality was similar (10% men versus 11.6% females, P = 0.257). Logistic regression analysis showed that sex is not significantly interacting with SOFA, SAPS or TISS-28. Additionally, there was no difference between male and females in score discrimination for ICU mortality. Conclusions. In a surgical ICU population, sex did not significantly change the validity of common intensive care unit scores. SOFA, SAPS and TISS-28 are comparable in female and male ICU-patients. A sex bias was not detected.
ER  -