TY  -  JOUR
AU  -  Brizuela, Martin
AU  -  Lenzi, Jacopo
AU  -  Ulloa-Gutiérrez, Rolando
AU  -  Antúnez-Montes, Omar Yassef
AU  -  Rios Aida, Jorge Alberto
AU  -  del Aguila, Olguita
AU  -  Arteaga-Menchaca, Erick
AU  -  Campos, Francisco
AU  -  Uribe, Fadia
AU  -  Parra Buitrago, Andrea
AU  -  Betancur Londoño, Lina Maria
AU  -  Gómez-Vargas, Jessica
AU  -  Yock-Corrales, Adriana
AU  -  Buonsenso, Danilo
T1  -  Influence of sex on disease severity in children with multisystem inflammatory syndrome and COVID-19 in Latin America
PY  -  2021
Y1  -  2021-09-01
DO  -  10.1723/3673.36590
JO  -  The Italian Journal of Gender-Specific Medicine
JA  -  Ital J Gender-Specific Med
VL  -  7
IS  -  3
SP  -  128
EP  -  133
PB  -  Il Pensiero Scientifico Editore
SN  -  2612-3487
Y2  -  2026/05/29
UR  -  http://dx.doi.org/10.1723/3673.36590
N2  -  Summary. Data from adult studies show that COVID-19 is more severe in men than women. However, no data are available for the pediatric population. For this reason, we performed this study aiming to understand if sex influenced disease severity and outcomes in a large cohort of Latin-American children with COVID-19 and multisystem inflammatory syndrome (MIS-C). We found that a higher percentage of male children developed MIS-C (8.9% vs 5% in females) and died (1.2% and 0.4% in females), although on multivariate adjusted analyses the only statistically significant difference was found in need of hospitalization, with females less frequently admitted compared with boys (25.6% vs 35.4%). This data are preliminary and need further independent studies to better assess the role of sex.
ER  -