TY  -  JOUR
AU  -  Castellino, Alessia
AU  -  Migliore, Elena
AU  -  Brignone, Chiara
AU  -  Grasso, Mariella
AU  -  Melchio, Remo
AU  -  Bonferroni, Margherita
AU  -  Cavallero, Giobatta
T1  -  Iron deficiency anemia and thrombosis in young women: a report of 9 cases
PY  -  2022
Y1  -  2022-01-01
DO  -  10.1723/3769.37562
JO  -  The Italian Journal of Gender-Specific Medicine
JA  -  Ital J Gender-Specific Med
VL  -  8
IS  -  1
SP  -  10
EP  -  17
PB  -  Il Pensiero Scientifico Editore
SN  -  2612-3487
Y2  -  2026/04/15
UR  -  http://dx.doi.org/10.1723/3769.37562
N2  -  Summary. Introduction. Iron deficiency anemia is more frequent in women of reproductive age than in men of the same age, and it is sometimes considered an irrelevant hematological condition. In literature, both arterial and venous thrombotic events associated with iron deficiency anemia have been reported in pediatric age and in young adults, more often in females. A pathophysiological role of erythrocytes in the onset of thrombosis is recognized in both genetic and acquired anemia. Methods. We report our experience with 9 young women in whom acute thrombosis, mostly venous, was associated with preexisting chronic iron deficiency anemia. Results. The contribution to the onset of thrombotic complications of both the hematological effects induced by iron deficiency and the individual pro-thrombotic factors was collected and analyzed. It can be hypothesized that a potential interaction between iron deficiency anemia and minor individual prothrombotic risk factors – both genetic and acquired – may increase the thrombotic risk for the first event and for any relapse. Discussion. According to our experience, an effective management of iron deficiency anemia, in addition to improving the quality of life of patients, could represent a preventive measure to reduce the individual thrombotic risk in young women, when exposed to physiological thrombophilic conditions, such as pregnancy, puerperium or oral contraceptives use and if genetic or acquired prothrombotic factors coexist with anemia.
ER  -