TY  -  JOUR
AU  -  Negro, Silvia
AU  -  Gennaro, Nicola
AU  -  Bao, Quoc Riccardo
AU  -  Ferroni, Eliana
AU  -  Capelli, Giulia
AU  -  Pucciarelli, Salvatore
AU  -  Spolverato, Gaya
AU  -  Zorzi, Manuel
T1  -  Gender differences in colorectal cancer surgery
PY  -  2024
Y1  -  2024-01-01
DO  -  10.1723/4235.42103
JO  -  Journal of Sex- and Gender-Specific Medicine
JA  -  J Sex Gender Specif Med
VL  -  10
IS  -  1
SP  -  29
EP  -  36
PB  -  Il Pensiero Scientifico Editore
SN  -  2974-8623
Y2  -  2026/05/14
UR  -  http://dx.doi.org/10.1723/4235.42103
N2  -  Summary. Introduction. Gender influences survival outcomes after colorectal cancer (CRC) treatments; however, its impact on CRC surgery remains largely unclear. This retrospective study aims to investigate gender differences in patients undergoing CRC resection, focusing on surgical treatments and postoperative outcomes. Methods. A total of 9,683 patients who underwent elective surgical resection for CRC were enrolled. Clinicopathological characteristics, operative details and outcomes were stratified by sex and analysed. Results. A total of 4,239 (44.8%) were female. Females were older at diagnosis (31.2% of women and 24.7% of men aged 80 years or older, p <0.001), with lower ASA score and Charlson comorbidity index (p <0.01). Males were more likely to have rectal tumours, while females right-sided tumours (p <0.01). Males were associated with a higher risk of anastomotic leakage, more stoma creation, and longer length of stay (LOS). Surgical complications were more common in females (p <0.01) and medical complications in males (p <0.01). On multivariable analysis, gender emerged as an independent predictor of both medical (male) and surgical (female) postoperative complications in colon cancer. Discussion. Females had more surgical complications after CRC resection, while males had a higher incidence of anastomotic leakage, a higher reoperation rate and a longer LOS.
ER  -