TY  -  JOUR
AU  -  Puoti, Francesca
AU  -  Masiero, Lucia
AU  -  Testa, Silvia
AU  -  Vespasiano, Francesca
AU  -  Oliveti, Alessandra
AU  -  Fiaschetti, Pamela
AU  -  Trapani, Silvia
AU  -  Peritore, Daniela
AU  -  Di Ciaccio, Paola
AU  -  Lombardi, Ilaria
AU  -  Cianchi, Tiziana
AU  -  Lombardini, Letizia
AU  -  Cardillo, Massimo
T1  -  Does sex matter in solid organ transplantation? Analysis of 20-year activity data from the Italian National Deceased Donor Transplant Register
PY  -  2024
Y1  -  2024-09-01
DO  -  10.1723/4343.43282
JO  -  Journal of Sex- and Gender-Specific Medicine
JA  -  J Sex Gender Specif Med
VL  -  10
IS  -  3
SP  -  115
EP  -  129
PB  -  Il Pensiero Scientifico Editore
SN  -  2974-8623
Y2  -  2026/06/09
UR  -  http://dx.doi.org/10.1723/4343.43282
N2  -  Summary. Introduction. In order to ensure equity and equality in transplant activity, sex and gender should be taken into account throughout the whole transplant process. This work analyses the male-female differences in Italy’s transplanted population, from waitlisting to transplantation and patient follow-up, over the past 20 years. Methods. Data from the Italian Transplant Information System were analysed by sex: patients listed for heart, kidney, liver and lung transplant; probability to be transplanted from deceased donors; graft (organ failure or patient death) survival by sex and donor-recipient sex combination. Results. Overall, 31% of patients enrolled on waiting lists are females (21% for heart, 26% for liver, 35% for kidney and 39% for lung); on average they are 2 years younger; they wait longer for a transplant, especially for lung, they receive however a heart transplant earlier than males. Moreover, females are less likely to receive a lung transplant but are favoured in case of heart transplant. Looking at the adjusted graft survival we found that by-sex donor-recipient combinations show a disadvantage for heart and lung transplant in female donor-male recipient: 77.1% and 64.7%, respectively, while they are over 80% and 70% for all other combinations. Discussion. Italian wait-listed and transplanted patients are very different by sex. The study results suggest that patient sex does not seem to be a key determinant of transplant outcome per se, but it rather helps in identifying populations with different risk profiles.
ER  -