TY  -  JOUR
AU  -  Chraa, Mohamed
AU  -  Klevor, Raymond
AU  -  Elmaouaki, Amal
AU  -  Kissani, Najib
T1  -  Impact of neuropsychiatric symptoms on quality of life in Parkinson’s disease: a focus on sex, age, and disease duration in a Moroccan cohort
PY  -  2024
Y1  -  2024-09-01
DO  -  10.1723/4343.43285
JO  -  Journal of Sex- and Gender-Specific Medicine
JA  -  J Sex Gender Specif Med
VL  -  10
IS  -  3
SP  -  149
EP  -  154
PB  -  Il Pensiero Scientifico Editore
SN  -  2974-8623
Y2  -  2026/06/25
UR  -  http://dx.doi.org/10.1723/4343.43285
N2  -  Summary. Introduction. The aim of this work is to investigate how neuropsychiatric symptoms impact the quality of life (QoL) in Parkinson’s disease (PD), and how these symptoms relate to sex, age and disease duration. Methods. This work is a cross-sectional, descriptive, and analytical study of patients with PD in a Moroccan cohort at an academic hospital using the Neuropsychiatric Inventory (NPI) and the Parkinson’s Disease Questionnaire (PDQ-8). Student’s t-test, Chi-square test, Fisher’s exact test, and one-way ANOVA were performed. Results. All patients (100%) were on L-dopa; 8 (25%) were on antidepressants. Neuropsychiatric symptoms were present in 29 out of 32 patients (90.6%), with clinically significant symptoms in 84.3%. Depression (75%), anxiety (65.6%), and irritability (62.5%) were the most frequent symptoms. Females reported higher NPI scores (p=0.008) and a higher number of symptoms (p=0.016). Among symptomatic patients, sleep problems were the most distressing. Depression (p=0.046) and age at onset (p=0.26) were correlated with QoL. Discussion. Neuropsychiatric symptoms are common in PD and negatively impact patients’ . Sex differences exist, with higher prevalence and more severe neuropsychiatric symptoms in our cohort. We did not find any differences in QoL across sex. However, early disease onset and younger age at the time of the study are associated with worse QoL outcomes.
ER  -