TY  -  JOUR
AU  -  Cardano, Miriana
AU  -  Buscemi, Giacomo
AU  -  Zannini, Laura
T1  -  A tale of sex-specificity in DNA damage response pathways: the paradigmatic story of TSPYL2
PY  -  2024
Y1  -  2024-09-01
DO  -  10.1723/4343.43287
JO  -  Journal of Sex- and Gender-Specific Medicine
JA  -  J Sex Gender Specif Med
VL  -  10
IS  -  3
SP  -  164
EP  -  166
PB  -  Il Pensiero Scientifico Editore
SN  -  2974-8623
Y2  -  2026/06/09
UR  -  http://dx.doi.org/10.1723/4343.43287
N2  -  Summary. Sexual dimorphism in cancer is still a poorly explored field but it is recognized that differences between males and females should depend not only on hormones and sex chromosomes, but also on molecular pathways generally considered to act equally in both sexes, such as the DNA damage response (DDR).Here, we will describe and discuss the sex specific regulation and function of the DDR protein TSPYL2 in cancer cells. We will highlight how these disparities could contribute to the different cancer predisposition and therapy outcome of males and females and the importance of considering sex in both basic research and clinical practice.
ER  -